A Protective Function of the Calcium Binding Protein S100A4 in Rat Hepatic Injury Due to Carbon Tetrachloride
نویسندگان
چکیده
Abstruct: F The role of the S100A4 in rat hepatocites was clarified by measuring detailed changes in serum ALT values and intracellular Ca2+ after CCl4 administration. In this study, we further showed that the calcium binding protein S100A4 might be a protein signal involved in the response to protect cells against CCl4 intoxication. S100A4 mRNA expression levels abruptly increased to a high level in normal liver at 1 day after CCl4 administration, and then gradually reduced to the control level by day 3. This change is the opposite to that of intracellular Ca2+.
منابع مشابه
The effect of hepatic protection of hydro alcoholic extract of Thyme in rats (Thymus daenensis).
Background Thyme has high antioxidant properties due to polyphenols and flavonoids. The aim of this study was to evaluate the effects of hepatic protection of Thyme on the toxicity induced by carbon tetrachloride in rats. Materials and methods In this experimental study, 40 male Wistar rats weighing 220-250 grams were randomly divided into five groups of eight. One group was monitored and f...
متن کاملHepatoprotective effects of licochalcone B on carbon tetrachloride-induced liver toxicity in mice
Objective(s): The objective of this study was to investigate the hepatoprotective effect of licochalcone B (LCB) in a mice model of carbon tetrachloride (CCl4)-induced liver toxicity. Materials and Methods: Hepatotoxicity was induced in mice by a single subcutaneous injection (SC) of CCl4. The LCB was administered orally once a day for seven days (PO) as pretreatment at three doses of 1, 5, and...
متن کاملAmelioration of carbon tetrachloride-induced hepatic injury by emulsified Antrodia extract
Objective(s): Antrodia cinnamomea (AC) is found with anti-inflammatory and immunomodulatory biological activities. In this study, we investigated the anti-hepatitis effect of the emulsified AC extract from RO water or supercritical fluid CO2 with ethanol co-solvent extract methods of AC preparations. Materials and Methods: Five groups of eight to ten weeks male rats with a count of ten for each...
متن کاملPotential Hepatoprotective Effect and Antioxidant Role of Methanol Extract of Oldenlandia Umbellata in Carbon Tetrachloride Induced Hepatotoxicity in Wistar Rats
The present work examines the protective mechanisms of methanol extract of Oldenlandia umbellata (MEOU) in carbon tetrachloride intoxicated rats. Rats were treated with carbon tetrachloride at the dose of 1 ml/kg body weight intraperitonially once in every 72 hrs for 16 days. The hepatoprotective activity of methanol extract of Oldenlandia umbellata was evaluated by measuring levels of serum ma...
متن کاملA Cytoprotection of Rat Hepatocytes Mediated by the Intracellular Calcium
The role of intracellular Ca2+ in CCl4 hepatotoxicity in rats was clarified by measuring detailed changes in serum ALT values and intracellular Ca2+ after CCl4 administration. Serum ALT activity clearly increased up to a peak value at 1 day after i.p. administration of CCl4 at 0.2 ml/kg, and then decreased to the control level after 3 days. Intracellular Ca2+ responded to CCl4 intoxication with...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره شماره
صفحات -
تاریخ انتشار 2006